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                What is One Pipeline?
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                            <p>How we’re advancing the best internal and external science to progress our pipeline for patients</p>
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                    <p class="mco-f1-article-hero-date text-descriptive">May 30, 2024</p>
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<p>Drug development is a long and difficult endeavor. It can take more than 10 years to bring a new medicine to market. So how does our company think about developing new medicines and vaccines to help save and improve lives? The answer: through our One Pipeline strategy, where we complement our internal innovation and discovery efforts with the best external science through business development.</p>



<div class="wp-block-columns mco-columns-wrapping is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex">
<div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"><div class="wp-block-image">
<figure class="aligncenter size-large is-resized"><img fetchpriority="high" decoding="async" width="666" height="664" src="https://www.merck.com/wp-content/uploads/sites/124/2020/12/ec-dean-li-1.jpg?w=666" alt="Dean Li" class="wp-image-2773514" style="width:333px;height:332px"/></figure></div></div>



<div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow">
<p>“Our One Pipeline strategy enables us to advance breakthrough science, whether it comes from our own labs or from our partners&#8217; labs, and make medicines and vaccines for patients,” said Dr. Dean Li, president, Merck Research Laboratories (MRL). “Every day, we’re pushing scientific boundaries in research. Business development and external partnerships are integral to help drive our internal pipeline and to provide access to assets that are important for our discovery and clinical development groups.”</p>
</div>
</div>



<p>To achieve that balance, MRL works in lockstep with our <a href="https://www.merck.com/research/business-development-and-licensing/">business development and licensing</a> (BD&amp;L) team. “I want to emphasize how integrated BD&amp;L is with MRL. This is hand in glove,” said Li.</p>



<h2 class="wp-block-heading">Business development augments our pipeline</h2>



<p>Our BD&amp;L team is committed to securing scientific and commercial collaborations, licensing agreements and acquisitions from discovery to late-stage candidates and new technologies to help build our robust portfolio. We have a legacy of successful collaborations and are among the most active <a href="https://www.merck.com/stories/new-podcast-meet-the-dealmakers/">dealmakers</a> in the biopharma industry.</p>



<div class="wp-block-columns mco-columns-wrapping is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex">
<div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow">
<figure class="wp-block-image size-full is-resized"><img decoding="async" width="2500" height="2100" src="https://www.merck.com/wp-content/uploads/sites/124/2024/11/W3862636_Sunil-Patel__021_EXT.png" alt="" class="wp-image-3659622" style="width:342px;height:auto"/></figure>
</div>



<div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow">
<p>“We match our strong scientific conviction with bold investments in novel, cutting-edge science to advance new options for patients,” said Sunil Patel, senior vice president, head of corporate development and BD&amp;L. “We’re focused on bringing in the best external science to complement our internal efforts to deliver on our purpose and sustain our company for the next 130 years.”</p>
</div>
</div>



<div class="wp-block-group art-stat-group mt-2 mb-2"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"><div id="art-stat-block-block_da4d4c93ff683833154d6eff891ad022" class="art-stat-block mccberg-block">
	<div class="stat-block-content  ">

		
		
		<div class="stat-block-statistic">~$50B</div>

		<div class="stat-block-tablet-wrapper">
						<p class="stat-block-description">Invested towards business development since 2019.</p>
			
					</div>

	</div>
</div>

<div id="art-stat-block-block_eecd77a23d3422ef5e72b05db674cec3" class="art-stat-block mccberg-block">
	<div class="stat-block-content  ">

		
		
		<div class="stat-block-statistic">~80</div>

		<div class="stat-block-tablet-wrapper">
						<p class="stat-block-description">Significant transactions executed annually across technologies, modalities, therapeutic areas and phases of development.</p>
			
					</div>

	</div>
</div></div></div>



<p>The BD&amp;L team members focused on our pipeline are embedded with scientists across our <a href="https://www.merck.com/research/rd-locations/">research network</a> and, in addition to our New Jersey and Pennsylvania sites, they&#8217;re strategically located in key epicenters of innovation including Boston, Cambridge, London, South San Francisco, Shanghai and Tokyo. The team searches the globe for cutting-edge science and works alongside our research team to evaluate opportunities built on strong scientific principles, regardless of location or origin.</p>



<h2 class="wp-block-heading">Creating a sustainable innovation engine</h2>



<div class="wp-block-columns mco-columns-wrapping is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex">
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<figure class="aligncenter size-large"><img decoding="async" width="6570" height="4380" src="https://www.merck.com/wp-content/uploads/sites/124/2024/05/Scientific-collaboration-2_HI.jpg?w=1024" alt="two scientists in a lab" class="wp-image-3649021"/></figure></div></div>



<div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow">
<p>As part of our One Pipeline strategy, we ensure a smooth transition when bringing in external science and leverage our clinical development and manufacturing expertise to advance each program with speed and rigor. This strategy is helping to build and maintain the flow of novel candidates through clinical development to patients, enabling long-term, sustainable growth for our company.</p>
</div>
</div>



<p>“Strategic business development focused on the best external science remains an important priority for our company. We’ve demonstrated that we can leverage our deep discovery prowess to identify important acquisition targets and then add significant value through our powerful clinical research engine, our regulatory expertise and our commercial scale, which together can serve to accelerate development and enable broad global access to important medical discoveries for patients in need,” said Rob Davis, chairman and chief executive officer.</p>



<div style="height:56px" aria-hidden="true" class="wp-block-spacer"></div>



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<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="500" height="333" src="https://www.merck.com/wp-content/uploads/sites/124/2023/11/Discovery-and-development-efforts2.jpg?w=500" alt="lab" class="wp-image-3637332"/></figure>



<h4 class="wp-block-heading">Pipeline</h4>



<p>We’re focused on discovering new medicines and vaccines for today and the future. View <a href="https://www.merck.com/research/product-pipeline/">our pipeline</a>.</p>
</div>



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<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="5472" height="3648" src="https://www.merck.com/wp-content/uploads/sites/124/2024/03/Header-photo2.png?w=1024" alt="people in a business meeting" class="wp-image-3644510"/></figure>



<h4 class="wp-block-heading">Business development and licensing</h4>



<p>We work with many partners, from early-stage science to clinical-stage programs, to deliver life-changing therapies. <a href="https://www.merck.com/research/business-development-and-licensing/">Learn more</a>.</p>
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* FileSaver.js
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*
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*
* License : https://github.com/eligrey/FileSaver.js/blob/master/LICENSE.md (MIT)
* source  : http://purl.eligrey.com/github/FileSaver.js
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    var configuredExternalLinks = ([{"title":"You are leaving Merck.com","message":"The link you have selected will direct you to a site outside of www.merck.com. We are Merck & Co. Inc., Rahway, NJ, USA known as MSD outside the United States and Canada. ","cancelBtnText":"Cancel","continueBtnText":"Proceed","domains":["*"]}] || []);


    /**
     * This function processes internal links for the Three Column Content Block.
     */
    function makeThreeColumnContentClickable(link, href, target) {
        if (link.role !== 'link' || !href) {
            return;
        }

        link.addEventListener('click', function(e) {

            e.preventDefault();
            e.stopPropagation();
            e.stopImmediatePropagation();

            var win = window.open(href, target);

            if (win) {
                win.focus();
            }
        });
    }

    if (typeof Array.prototype.some !== 'function') {
        Array.prototype.some = function(predicate, thisArg) {
            if (typeof predicate !== 'function') {
                throw TypeError('Array.prototype.some(): predicate must be a function.');
            }

            for (var i = 0; i < this.length; i++) {
                if (predicate.call(thisArg, this[i], i, this)) {
                    return true;
                }
            }

            return false;
        };
    }

    function processLink(link) {

        if (!link || ! ['A', 'DIV'].includes(link.nodeName) || link.classList.contains('external-link-with-popup')) {
            return;
        }

        var href = link.dataset.href || link.href;

        if (!href) {
            return;
        }

        var target = link.dataset.target || link.target || '_self';

        if (shouldAllowDomain(href)) {
            //process internal links
            makeThreeColumnContentClickable(link, href, target);
            return;
        }

        link.addEventListener('click', function(e) {
            e.preventDefault();

            e.stopPropagation();

            e.stopImmediatePropagation();

            var modalData = getExternalLinkContent(href);

            if (!modalData) {
                var win = window.open(href, target);

                if (win) {
                    win.focus();
                }

                return;
            }

            var modal = document.getElementById('externalLinkModal');
            var modalTitle = document.getElementById('externalLinkModalTitle');
            var modalCancelBtn = document.getElementById('externalLinkCancelBtn');
            var modalMessage = document.getElementById('externalLinkModalMessage');
            var modalContinueLink = document.getElementById('externalLinkModalBtn');

            if (link.dataset.src === 'karma-release' && !true) {
                modalData.message = 'This content is not available to residents outside the US and Canada';
                modalData.title = '';
                modalData.cancelBtnText = 'Ok';
                modalContinueLink.style.display = 'none';
            }

            if (modalTitle) {
                modalTitle.textContent = modalData.title;
            }

            if (modalMessage) {
                modalMessage.textContent = modalData.message;
            }

            if (modalCancelBtn) {
                modalCancelBtn.textContent = modalData.cancelBtnText || 'Cancel';
            }

            if (modalContinueLink) {
                modalContinueLink.href = href;
                modalContinueLink.target = target;
                modalContinueLink.textContent = modalData.continueBtnText || 'Proceed';
            }

            if (modal) {
                if (modal.style.display === 'none') {
                    modal.style.display = 'block';
                    modalCancelBtn.focus();
                } else {
                    modal.style.display = 'none';
                }
            }

            // Trap focus within the modal
            modal.addEventListener('keydown', (event) => {
                const focusableElements = [modalCancelBtn, modalContinueLink];
                const firstElement = focusableElements[0];
                const lastElement = focusableElements[1];

                if (event.key === 'Tab') {
                    if (event.shiftKey) { // Shift + Tab
                        if (document.activeElement === firstElement) {
                            lastElement.focus();
                            event.preventDefault();
                        }
                    } else { // Tab
                        if (document.activeElement === lastElement) {
                            firstElement.focus();
                            event.preventDefault();
                        }
                    }
                }
            });

            modalCancelBtn.addEventListener('click', () => {
                closeExternalLinkModal();
                link.focus();
            });
        });
        link.setAttribute('role', 'button');
        link.setAttribute('aria-haspopup', 'true');
        link.classList.add('external-link-with-popup');
    }

    for (var i = 0; i < documentLinks.length; i++) {
        processLink(documentLinks[i]);
    }

    function getExternalLinkContent(link) {
        var wildCardLinks = [];

        for (var i = 0; i < configuredExternalLinks.length; i++) {
            var configuredExternalLink = configuredExternalLinks[i];

            for (var j = 0; j < configuredExternalLink.domains.length; j++) {
                var domain = configuredExternalLink.domains[j];

                if (domain === '*') {
                    wildCardLinks.push(configuredExternalLink);
                }

                if (link.indexOf(domain) !== -1) {
                    return configuredExternalLink;
                }
            }
        }

        if (!wildCardLinks.length) {
            return null;
        }

        return wildCardLinks[0];
    }

    function stripHttpsWWW(link){
        return link.replace(/^(https?:\/\/)?(www\.)?/i, '');
    }

    function shouldAllowDomain(link) {
        //get the domain text without the http or https or www.
        var urlParts = stripHttpsWWW(link).split('/');

        if (!urlParts.length) {
            return false;
        }

        var domain = urlParts[0];
        var currentDomain = stripHttpsWWW(document.location.hostname);

        // Allow if the domain matches the current domain
        if (domain === currentDomain) {
            return true;
        }

        // Check if the domain is in the allowed domains
        if (allowedDomains.some(function(allowedDomain) {

            // Check if it's a protocol (e.g., tel:, mailto:, javascript:)
            if (link.startsWith(allowedDomain)) {
                return true;
            }

            if (allowedDomain.startsWith('REGEXP:')) {
                let allowedDomainRegex = new RegExp(allowedDomain.replace('REGEXP:', ''), 'g');
                if (allowedDomainRegex.test(link)) {
                    return true
                }
            }

            allowedDomain = stripHttpsWWW(allowedDomain);
            return domain === allowedDomain || domain.endsWith(`.${allowedDomain}`);
        })) {
            return true;
        }

        return false;
    }

    function isSubdomain(domain) {
        return domain.split('.').length !== 2;
    }

    function closeExternalLinkModal() {
        var modal = document.getElementById('externalLinkModal');

        if (modal) {
            modal.style.display = 'none';
        }
    }

    try {
        // Switching to MutationObserver to apply External Link feature to dynamic DOM.
        // Options for the observer (which mutations to observe)
        const mcc_el_observer_config = { attributes: false, childList: true, subtree: true };

        // Callback function to execute when mutations are observed
        const pageMutatedHandler = function(mutationsList) {
            for(const mutation of mutationsList) {
                mutation?.addedNodes?.forEach(link => processLink(link));
            }
        };

        // Create an observer instance linked to the callback function
        const mcc_el_observer = new MutationObserver(pageMutatedHandler);

        // Start observing the target node for configured mutations
        mcc_el_observer.observe(document.querySelector('#page'), mcc_el_observer_config);
    } catch(err) {
        console.log(err);
    }

</script>
<div id="ukUserModal" class="popup" style="display: none;">
    <div class="popup-wrapper">
        <div class="popup-content foward-guide-modal-content">

            <h3></h3>

            <div class="forward-guidance-content">
                <p style="max-width: 31.25rem;"></p>
            </div>

            <div class="btn-container text-center">
                <a target="_blank" class="btn tertiary negative" id="externalLinkModalBtn" onclick="AcceptUKMessage();">
                                    </a>
            </div>

        </div>
    </div>
</div>

<script type="text/javascript">
    function AcceptUKMessage() {
        try {
            let accepted = {
                expire: new Date(new Date().getTime() + 60 * 60 * 24 * 1000)
            };
            sessionStorage.setItem('uk-messaging', JSON.stringify(accepted));
            document.getElementById('ukUserModal').style.display = 'none';
        } catch (ex) {
            console.log(ex);
        }
    }
</script>



<script>
    removeTopBorderFromSeparatorBlock();

    function removeTopBorderFromSeparatorBlock() {
        let separatorBlock = document.querySelectorAll('.wp-block-separator.is-style-wide');
        for (let i = 0; i < separatorBlock.length; i++) {
            separatorBlock[i].style.borderTop = '0px';
        }
    }
    // Set the offset when entering page with hash present in the url
    document.addEventListener('DOMContentLoaded', (e) => {
        if (location.hash.length !== 0) {
            accordionFocus();
        }

        function accordionFocus() {
            const URL = window.location.href;
            const splittedURL = URL.split('/');
            //accordion id should be at the end
            const possibleAccordionID = splittedURL[splittedURL.length - 1];
            const RegExp = /#[a-zA-Z-\d]+/gi;
            const foundAccordionMatch = RegExp.test(possibleAccordionID);
            //Check if param was found
            if (foundAccordionMatch) {
                setTimeout(function() {
                    let accordionName = possibleAccordionID.match(RegExp).toString();
                    const accordionId = accordionName.replace('#', '');
                    let accordionControl = document.getElementById(accordionId);

                    if (accordionControl && accordionControl.closest('.b6-accordion-list-item-details')) {
                        allA6Tabs = document.querySelectorAll('.mccberg-tab-content');
                        if(allA6Tabs.length > 0){
                            openA6tab(allA6Tabs, accordionControl)
                        }
                        //get the element closest to the collapse handle
                        let accordionDetail = accordionControl.closest('.b6-accordion-list-item-details')
                        accordionDetail.setAttribute('open', " ");
                        accordionDetail.scrollIntoView();
                    }
                }, 500);
            }
        }

    });

    function openA6tab(allA6Tabs, accordionControl)
    {
    //close all A6tabs and Title
    allA6TabsTitle = document.querySelectorAll('.mccberg-tab-title');
    for (let i = 0; i < allA6Tabs.length; i++) {
        allA6Tabs[i].classList.remove('open');
        allA6TabsTitle[i].classList.remove('open');
    }
    let accordionDetailA6 = accordionControl.closest('.mccberg-tab-content')

    // Assuming accordionDetailA6 is the element you are working with
    let matchedClass = Array.from(accordionDetailA6.classList).find(className => 
    className.startsWith('mccberg-tab-content-')
    );
    // Extract the number at the end of the matched class
    let indexNumber = matchedClass ? matchedClass.split('-').pop() : null;

    // Output the number
    allA6TabsTitle[indexNumber-1].classList.add('open')
    accordionDetailA6.classList.add('open');
    }
    function idLinkScrollFix(hash) {
        setTimeout(function() {

            var one_trust_cookie_panel = document.getElementById("onetrust-banner-sdk");
            let wp_admin_bar = document.getElementById('wpadminbar');
            let admin_bar_offset_height = wp_admin_bar ? wp_admin_bar.offsetHeight : 0;
            let cookie_present = one_trust_cookie_panel && !one_trust_cookie_panel.style.visibility;
            let cookie_gone = one_trust_cookie_panel && one_trust_cookie_panel.style.visibility === 'hidden';
            let cookie_height = cookie_present && !cookie_gone ? one_trust_cookie_panel.offsetHeight : 0;
            let mastheadElement = document.getElementById('masthead');
            let masthead = mastheadElement ? mastheadElement.offsetHeight : 0;
            let brand_headerElement = document.getElementsByClassName('brand-header')[0];
            let brand_header = brand_headerElement ? brand_headerElement.offsetHeight : 0;
            let height_to_adjust = admin_bar_offset_height + masthead + brand_header + cookie_height + 16;
            let el_to_scroll_to = document.getElementById(hash.replace("#", ''));
            if (el_to_scroll_to) {
                let position = el_to_scroll_to.getBoundingClientRect();
                window.scrollTo(position.left, position.top - height_to_adjust + window.scrollY);
            }
        }, 500);
    }
</script>
</body>

</html>
